Cerebrospinal fluid protein carbonylation identifies oxidative damage in autoimmune demyelination
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چکیده
منابع مشابه
Cerebrospinal fluid protein carbonylation identifies oxidative damage in autoimmune demyelination
Oxidative damage occurs in multiple sclerosis, but is difficult to identify antemortem and remains an unknown contributor to disease progression. Carbonylation is a quantitative measure of protein oxidation. Cerebrospinal fluid samples from multiple sclerosis patients showed elevated carbonylated protein levels compared to controls. In experimental autoimmune encephalomyelitis, carbonylated pro...
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An extensive body of evidence indicates that oxidative stress and inflammation play a central role in the degenerative changes of systemic tissues in aging. However a comparatively limited amount of data is available to verify whether these processes also contribute to normal aging within the brain. High levels of oxidative damage results in key cellular changes including a reduction in availab...
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متن کاملRole of oxidative carbonylation in protein quality control and senescence.
Proteins can become modified by a large number of reactions involving reactive oxygen species. Among these reactions, carbonylation has attracted a great deal of attention due to its irreversible and unrepairable nature. Carbonylated proteins are marked for proteolysis by the proteasome and the Lon protease but can escape degradation and form high-molecular-weight aggregates that accumulate wit...
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ژورنال
عنوان ژورنال: Annals of Clinical and Translational Neurology
سال: 2016
ISSN: 2328-9503
DOI: 10.1002/acn3.379